Sepahan humiliated Mes 4-0 in a home game and regained the top.
Elsewhere, Traktorsazi beat Sanat Naft of Abadan 4-1 in Tabriz while Naft beat Malavan 1-0.
Sepahan sits atop the league table, two points ahead of Esteghlal and Traktorsazi is third, three points adrift.