Nekounam was sidelined since being injured on his knee by Uruguayan striker Sebastian Soria in Iran's World Cup qualifier against Qatar in Doha on September 7 (1-1), his 31st birthday.
Without the defensive midfielder and his still injured compatriot Masoud Shojaei, Osasuna defeated Sporting Gijon 2-1, but were hammered 8-0 by mighty FC Barcelona last weekend before struggling to a goalless draw against Sevilla in midweek.
While Nekounam, who resumed training with the team this week, will at least make the bench, Shojaei is still recovering from a nasty foot injury he suffered in La Liga last season.