In the match held at the Takhti Stadium in Tehran, Hossein Kazemi put the visitors ahead after 22 minute.
Milorad Janjus’s header equalized the match in the 64nd minute, and Ibrahima Toure scored the winning goal for Sepahan 15 minutes later.
Elsewhere, A 2-1 victory over Shahin Bushehr was enough for Zob Ahan to keep top of the Iran Pro League.
Other IPL results are as follows:
* Malavan 2 - Perspolis 1
* Esteghlal 2 - Saba 0