Amin Motevaselzadeh and Bahador Abdi had given the visitors the lead on two occasions, only for Sepahan to equalise first through and then Seyed Jalal Hosseini and then Mohsen Bengar, who levelled with 14 minutes to go.
Steel Azin moved off the bottom thanks to Siavash Akbarpour's double in a 2-1 home win over Foolad. Bakary Diakite replied for the visitors.
Karrar Jassim's first-half goal sealed a 1-0 win for Teraktor Sazi FC over Perspolis while Naft Tehran and Malavan played out a goalless draw.